Gentamicin

Garamycin, Gentacalm, Genone, Motazol, Otomax, Mometamax, Garasol, Gentak, Pred-G, Mometavet, Mometamax Single, GentaVed

Antibiotic • Aminoglycoside

Premium

NTINephrotoxic

Half-life

2-3 hours

Protein Binding

0-30%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Nephrotoxicity
Ototoxicity (may be irreversible)
Neuromuscular blockade and respiratory paralysis

Clinical alerts

Boxed warning

3 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Binds to 30S ribosomal subunit, causing misreading of mRNA and bacterial death

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Osteomyelitis
·Interstitial Cystitis
·Levator Spasm
·Bladder Pain Syndrome
·Septic Abortion

Dosing

Typical adult starting point — always confirm against local guidelines

Typical dose: [object Object] mg every 24 h; Intravenous

Monitoring

Therapeutic range: 0–2 mg/L; Trough
Peak range: 6–10 mg/L
Steady state: ~12 hours
Re-check: At least twice weekly

Trough: before next dose
Peak: 30 min after infusion end

Interactions

No curated interaction pairs are recorded for Gentamicin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nephrotoxicity
Ototoxicity
Vestibular toxicity
Neuromuscular blockade

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Published parameters · PMID:3888543

Half-life: 2-3 hours
Protein binding: 0-30%
Clearance: 5.4 L/h; adult patients
Volume of distribution: 18 L
Renally eliminated: 95%; Dose review in renal impairment
Model: 2-compartment

Pregnancy & lactation

Not recorded for Gentamicin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, published PK literature, TDM population profiles.

Not a substitute for clinical judgement

Gentamicin

Garamycin, Gentacalm, Genone, Motazol, Otomax, Mometamax, Garasol, Gentak, Pred-G, Mometavet, Mometamax Single, GentaVed

Antibiotic • Aminoglycoside

Premium

NTINephrotoxic

Half-life

2-3 hours

Protein Binding

0-30%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Nephrotoxicity
Ototoxicity (may be irreversible)
Neuromuscular blockade and respiratory paralysis

Clinical alerts

Boxed warning

3 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Binds to 30S ribosomal subunit, causing misreading of mRNA and bacterial death

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Osteomyelitis
·Interstitial Cystitis
·Levator Spasm
·Bladder Pain Syndrome
·Septic Abortion

Dosing

Typical adult starting point — always confirm against local guidelines

Typical dose: [object Object] mg every 24 h; Intravenous

Monitoring

Therapeutic range: 0–2 mg/L; Trough
Peak range: 6–10 mg/L
Steady state: ~12 hours
Re-check: At least twice weekly

Trough: before next dose
Peak: 30 min after infusion end

Interactions

No curated interaction pairs are recorded for Gentamicin. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nephrotoxicity
Ototoxicity
Vestibular toxicity
Neuromuscular blockade

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Pharmacokinetics

Published parameters · PMID:3888543

Half-life: 2-3 hours
Protein binding: 0-30%
Clearance: 5.4 L/h; adult patients
Volume of distribution: 18 L
Renally eliminated: 95%; Dose review in renal impairment
Model: 2-compartment

Pregnancy & lactation

Not recorded for Gentamicin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, published PK literature, TDM population profiles.

Not a substitute for clinical judgement

Gentamicin Drug Profile | PharmaGraphX