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  3. /Gabapentin

Gabapentin

Neurontin, Gralise, Horizant, Gabarone

Anticonvulsant • GABA analog / Calcium channel modulator

Premium
CNS Depressant

Half-life

5-7 hours

Protein Binding

Metabolized By

CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4

External

Drugs.com

Mechanism of Action

Binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release

Classification

Drug Class

Anticonvulsant

Subclass

GABA analog / Calcium channel modulator

Brand Names

NeurontinGraliseHorizantGabarone

Key Properties

Half-life

5-7 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Gabapentin Drug Profile | PharmaGraphX