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Fluphenazine

Uncategorized

Standard

Half-life

15-24 hours (oral); 6.8-9.6 days (decanoate)

Protein Binding

91-99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Potent D2 receptor antagonist; available as long-acting decanoate injection

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Schizophrenia
·Psychosis
·Mania
·Pregnancy
·Drug Exposure in Utero

Interactions

No curated interaction pairs are recorded for Fluphenazine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

EPS
Akathisia
Tardive dyskinesia
Dystonia

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Pharmacokinetics

Half-life: 15-24 hours (oral); 6.8-9.6 days (decanoate)
Protein binding: 91-99%
Metabolised by: CYP2D6

Pregnancy & lactation

Not recorded for Fluphenazine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Fluphenazine

Uncategorized

Standard

Half-life

15-24 hours (oral); 6.8-9.6 days (decanoate)

Protein Binding

91-99%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Increased mortality in elderly with dementia-related psychosis

Clinical alerts

Boxed warning

1 boxed warning

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Potent D2 receptor antagonist; available as long-acting decanoate injection

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Schizophrenia
·Psychosis
·Mania
·Pregnancy
·Drug Exposure in Utero

Interactions

No curated interaction pairs are recorded for Fluphenazine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

EPS
Akathisia
Tardive dyskinesia
Dystonia

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Pharmacokinetics

Half-life: 15-24 hours (oral); 6.8-9.6 days (decanoate)
Protein binding: 91-99%
Metabolised by: CYP2D6

Pregnancy & lactation

Not recorded for Fluphenazine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement