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  3. /Fluoxetine

Fluoxetine

Prozac, Sarafem, Symbyax, RECONCILE

Antidepressant • SSRI

Premium
QT RiskBleedingSerotoninergic

Half-life

1-3 days (norfluoxetine 4-16 days)

Protein Binding

Metabolized By

CYP2D6, CYP2C9

External

Drugs.com

Mechanism of Action

Selectively inhibits serotonin reuptake; active metabolite norfluoxetine

Indications(5)

Older AdultsAnxietyDepressionMajor Surgical Resection of a Thoracic MalignancyMajor Surgical Resection of an Abdominal Malignancy

Classification

Drug Class

Antidepressant

Subclass

SSRI

Brand Names

ProzacSarafemSymbyaxRECONCILE

Key Properties

Half-life

1-3 days (norfluoxetine 4-16 days)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Fluoxetine Drug Profile | PharmaGraphX