Cardiovascular death — higher rate vs allopurinol (CARES trial); use only if allopurinol is ineffective/intolerable
Clinical alerts
Boxed warning
1 boxed warning
Hepatotoxic
Monitor liver function
Mechanism of action
Selectively inhibits xanthine oxidase (both oxidized and reduced forms)
Interactions
No curated interaction pairs are recorded for Febuxostat. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Nausea
Arthralgia
Elevated LFTs
Rash
Food, alcohol & herbal
Alcohol · moderate
Alcohol increases uric acid
Pharmacokinetics
Half-life
5-8 hours
Protein binding
99.2%
Metabolised by
CYP1A2, CYP2C8, CYP2C9
Pregnancy & lactation
Not recorded for Febuxostat. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
