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  3. /Ethinyl Estradiol/Levonorgestrel

Ethinyl Estradiol/Levonorgestrel

Alesse, Levlen, Nordette, Trivora

Contraceptive • Combined oral contraceptive

Premium
Hepatotoxic

Half-life

EE: 12-23 hours; LNG: 24-32 hours

Protein Binding

Metabolized By

CYP3A4, UGT

External

Drugs.com

Mechanism of Action

Suppresses ovulation via negative feedback on hypothalamus; thickens cervical mucus

Classification

Drug Class

Contraceptive

Subclass

Combined oral contraceptive

Brand Names

AlesseLevlenNordetteTrivora

Key Properties

Half-life

EE: 12-23 hours; LNG: 24-32 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ethinyl Estradiol/Levonorgestrel Drug Profile | PharmaGraphX