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  3. /Etanercept

Etanercept

Enbrel, Erelzi, Eticovo

Biologic • TNF-alpha inhibitor

Premium

Half-life

102 hours

Protein Binding

Metabolized By

Proteolytic degradation

External

Drugs.com

Mechanism of Action

Fusion protein (TNF receptor + IgG1 Fc) that binds and inactivates TNF-alpha

Indications(5)

Rheumatoid ArthritisPolyarticular Course Juvenile Idiopathic Arthritis (JIA)Juvenile Idiopathic ArthritisModerate-to-severe Chronic Plaque PsoriasisPsoriasis

Classification

Drug Class

Biologic

Subclass

TNF-alpha inhibitor

Brand Names

EnbrelErelziEticovo

Key Properties

Half-life

102 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Etanercept Drug Profile | PharmaGraphX