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  3. /Esomeprazole

Esomeprazole

Nexium, Nexium 24HR, Vimovo

Proton pump inhibitor • PPI

Premium
Nephrotoxic

Half-life

1-1.5 hours

Protein Binding

Metabolized By

CYP2C19, CYP3A4

External

Drugs.com

Mechanism of Action

S-isomer of omeprazole; irreversibly inhibits proton pump

Indications(5)

Early Gastric CancerGastric DysplasiaGastric NeoplasmsPeptic Ulcer With HaemorrhageGastric Ulcer

Classification

Drug Class

Proton pump inhibitor

Subclass

PPI

Brand Names

NexiumNexium 24HRVimovo

Key Properties

Half-life

1-1.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Esomeprazole Drug Profile | PharmaGraphX