Fetal toxicity — discontinue when pregnancy detected
Clinical alerts
Boxed warning
1 boxed warning
Mechanism of action
Prodrug converted to enalaprilat; inhibits ACE, reducing angiotensin II and aldosterone
Recorded indications
From the drug index — may include conditions studied rather than approved indications
·Alport Syndrome, X-Linked
·Hypertension (HTN)
·Diarrhea
·Pneumonia
·Malaria Fever
Interactions
No curated interaction pairs are recorded for Enalapril. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Cough
Hyperkalemia
Dizziness
Hypotension
Food, alcohol & herbal
Food
Potassium-rich foods and potassium-containing salt substitutes may worsen hyperkalemia
Alcohol · moderate
Additive hypotension
Pharmacokinetics
Half-life
11 hours (enalaprilat)
Protein binding
50-60%
Metabolised by
CYP3A4
Pregnancy & lactation
Pregnancy category
D
Sources
Assembled from: drug index, curated drug database.
