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  3. /Empagliflozin

Empagliflozin

Jardiance, Glyxambi, Synjardy, Trijardy

Antidiabetic • SGLT2 inhibitor

Premium

Half-life

12.4 hours

Protein Binding

Metabolized By

UGT1A3, UGT1A8, UGT1A9, UGT2B7

External

Drugs.com

Mechanism of Action

Inhibits sodium-glucose co-transporter 2 in proximal tubule, increasing urinary glucose excretion

Classification

Drug Class

Antidiabetic

Subclass

SGLT2 inhibitor

Brand Names

JardianceGlyxambiSynjardyTrijardy

Key Properties

Half-life

12.4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Empagliflozin Drug Profile | PharmaGraphX