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  3. /Doxepin

Doxepin

Sinequan, Silenor, Prudoxin, Zonalon

Antidepressant • Tricyclic antidepressant (TCA)

Premium
NTIQT RiskSerotoninergicCNS Depressant

Half-life

8-24 hours

Protein Binding

Metabolized By

CYP2C19, CYP2D6

External

Drugs.com

Mechanism of Action

Inhibits norepinephrine and serotonin reuptake; potent H1 antihistamine

Indications(5)

Acute Oral Mucositis PainSwallowing-induced PainItchBipolar DisorderFunctional Gastrointestinal Disorders

Classification

Drug Class

Antidepressant

Subclass

Tricyclic antidepressant (TCA)

Brand Names

SinequanSilenorPrudoxinZonalon

Key Properties

Half-life

8-24 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Doxepin Drug Profile | PharmaGraphX