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Sinequan, Silenor
Antidepressant • Tricyclic antidepressant (TCA)
Inhibits norepinephrine and serotonin reuptake; potent H1 antihistamine
Drug Class
Antidepressant
Subclass
Tricyclic antidepressant (TCA)
Half-life
8-24 hours
Time for plasma concentration to decrease by 50%
Protein Binding
80%
Fraction bound to plasma proteins
Therapeutic Index
Narrow
Margin between therapeutic and toxic doses