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  3. /Donepezil

Donepezil

Aricept, Aricept ODT

Anti-dementia • Cholinesterase inhibitor

Premium
QT Risk

Half-life

70 hours

Protein Binding

Metabolized By

CYP2D6, CYP3A4

External

Drugs.com

Mechanism of Action

Reversibly inhibits acetylcholinesterase, increasing ACh in the synapse

Classification

Drug Class

Anti-dementia

Subclass

Cholinesterase inhibitor

Brand Names

AriceptAricept ODT

Key Properties

Half-life

70 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Donepezil Drug Profile | PharmaGraphX