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Antabuse
Alcohol deterrent • Aldehyde dehydrogenase inhibitor
Irreversibly inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation with alcohol
Drug Class
Alcohol deterrent
Subclass
Aldehyde dehydrogenase inhibitor
Half-life
60-120 hours
Time for plasma concentration to decrease by 50%
Protein Binding
96%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses