Diazepam

Valium, Diastat, Valtoco, Libervant

Benzodiazepine • Long-acting benzodiazepine

Premium

CNS Depressant

Half-life

20-100 hours

Protein Binding

98%

Metabolized By

CYP2C19, CYP3A4, CYP2B6

External

Drugs.com

Boxed warning

Opioid co-use risks CNS depression/death
Dependence and withdrawal

Clinical alerts

Boxed warning

2 boxed warnings

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Enhances GABA-A receptor activity

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Endoscopic Retrograde Cholangiopancreatography
·Conscious Sedation Adverse Event
·Procedural Pain
·Sedation-related Complications
·Epilepsy

Interactions

3 curated · 3 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
fentanyl	contraindicated	High risk of fatal respiratory depression
heroin	contraindicated	Severe respiratory depression, high overdose mortality
morphine	contraindicated	Life-threatening respiratory depression.

Common adverse effects

Sedation
Ataxia
Memory impairment
Dependence

Food, alcohol & herbal

Food

Grapefruit may increase levels

Alcohol · major

Profound CNS depression. CONTRAINDICATED.

Herbal

Kava (major) — Additive CNS depression

Pharmacokinetics

Half-life: 20-100 hours
Protein binding: 98%
Metabolised by: CYP2C19, CYP3A4, CYP2B6

Pregnancy & lactation

Not recorded for Diazepam. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Diazepam

Valium, Diastat, Valtoco, Libervant

Benzodiazepine • Long-acting benzodiazepine

Premium

CNS Depressant

Half-life

20-100 hours

Protein Binding

98%

Metabolized By

CYP2C19, CYP3A4, CYP2B6

External

Drugs.com

Boxed warning

Opioid co-use risks CNS depression/death
Dependence and withdrawal

Clinical alerts

Boxed warning

2 boxed warnings

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Enhances GABA-A receptor activity

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Endoscopic Retrograde Cholangiopancreatography
·Conscious Sedation Adverse Event
·Procedural Pain
·Sedation-related Complications
·Epilepsy

Interactions

3 curated · 3 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
fentanyl	contraindicated	High risk of fatal respiratory depression
heroin	contraindicated	Severe respiratory depression, high overdose mortality
morphine	contraindicated	Life-threatening respiratory depression.

Common adverse effects

Sedation
Ataxia
Memory impairment
Dependence

Food, alcohol & herbal

Food

Grapefruit may increase levels

Alcohol · major

Profound CNS depression. CONTRAINDICATED.

Herbal

Kava (major) — Additive CNS depression

Pharmacokinetics

Half-life: 20-100 hours
Protein binding: 98%
Metabolised by: CYP2C19, CYP3A4, CYP2B6

Pregnancy & lactation

Not recorded for Diazepam. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Diazepam Drug Profile | PharmaGraphX