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  3. /Cyclosporine

Cyclosporine

Sandimmune, Neoral, Gengraf, Optimmune, Cequa, Cyclavance, Verkazia, Vevye, Sporimune, Modulis, Restasis, Atopica

Immunosuppressant • Calcineurin inhibitor

Premium
NTIHepatotoxicNephrotoxic

Half-life

8-27 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Binds to cyclophilin, inhibiting calcineurin and preventing T-cell activation

Indications(5)

Atopic DermatitisNephrotic SyndromeProteinuriaAutoimmune DiseaseGlomerular Disease

Classification

Drug Class

Immunosuppressant

Subclass

Calcineurin inhibitor

Brand Names

SandimmuneNeoralGengrafOptimmuneCequaCyclavanceVerkaziaVevyeSporimuneModulisRestasisAtopica

Key Properties

Half-life

8-27 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Cyclosporine Drug Profile | PharmaGraphX