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  3. /Cyclobenzaprine

Cyclobenzaprine

Flexeril, Amrix, Tonmya, Fexmid

Muscle relaxant • Centrally acting skeletal muscle relaxant

Premium
QT RiskSerotoninergicCNS Depressant

Half-life

18 hours

Protein Binding

Metabolized By

CYP1A2, CYP3A4, CYP2D6

External

Drugs.com

Mechanism of Action

Reduces muscle spasm through action at the brainstem; structurally related to TCAs

Indications(5)

Healthy Subjects (HS)High Tone Pelvic Floor DysfunctionPharmakokineticOpen LabelPhase 1

Classification

Drug Class

Muscle relaxant

Subclass

Centrally acting skeletal muscle relaxant

Brand Names

FlexerilAmrixTonmyaFexmid

Key Properties

Half-life

18 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Cyclobenzaprine Drug Profile | PharmaGraphX