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Colchicine

Colcrys, Mitigare, Gloperba, Lodoco

Antigout • Anti-inflammatory (microtubule inhibitor)

Premium
NTI

Half-life

27-31 hours

Protein Binding

Metabolized By

CYP3A4, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1

External

Drugs.com

Mechanism of Action

Disrupts microtubule assembly, inhibiting neutrophil migration and inflammatory response

Classification

Drug Class

Antigout

Subclass

Anti-inflammatory (microtubule inhibitor)

Brand Names

ColcrysMitigareGloperbaLodoco

Key Properties

Half-life

27-31 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Colchicine Drug Profile | PharmaGraphX