Clozapine

Clozaril, FazaClo, Versacloz

Antipsychotic • Second-generation (atypical) antipsychotic

NTIQT RiskCNS Depressant

Half-life

8-12 hours

Protein Binding

97%

Metabolized By

CYP1A2, CYP3A4

External

Antagonizes D4, 5-HT2A, H1, muscarinic, and alpha-1 receptors with weak D2 affinity

Drug Class

Antipsychotic

Subclass

Second-generation (atypical) antipsychotic

ClozarilFazaCloVersacloz

Half-life

8-12 hours

Time for plasma concentration to decrease by 50%

Protein Binding

97%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses