PharmaGraphX

Log in Get Started

Clonidine

Kapvay, Nexiclon, Catapres, Clorpres, Duraclon, Onyda, Javadin

Uncategorized

Standard

Half-life

12-16 hours

Protein Binding

20-40%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Stimulates alpha-2 adrenergic receptors in brainstem, reducing sympathetic outflow

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·PTSD
·Posttraumatic Stress Disorder
·Sleep
·Post-Mastectomy Neuropathic Pain Syndrome
·Acute Pain

Interactions

No curated interaction pairs are recorded for Clonidine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Dry mouth
Drowsiness
Dizziness
Constipation

Food, alcohol & herbal

Alcohol · major

Severe CNS depression and hypotension

Pharmacokinetics

Half-life: 12-16 hours
Protein binding: 20-40%
Metabolised by: CYP2D6

Pregnancy & lactation

Not recorded for Clonidine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement