Celecoxib Drug Profile | PharmaGraphX

Boxed warning

Cardiovascular thrombotic events (may be higher than other NSAIDs)
GI bleeding, ulceration, perforation
Sulfonamide allergy cross-reactivity

Clinical alerts

Boxed warning

3 boxed warnings

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Selectively inhibits COX-2, reducing inflammatory prostaglandins with less GI toxicity

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Metastatic Oral Cavity Carcinoma
·Recurrent Oral Cavity Carcinoma
·Stage IVC Lip and Oral Cavity Cancer AJCC v8
·Osteoarthritis of the Knee
·Diffuse Large B-Cell Lymphoma (DLBCL)

Interactions

No curated interaction pairs are recorded for Celecoxib. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Abdominal pain
Diarrhea
Dyspepsia
Flatulence
Edema

Food, alcohol & herbal

Food

High-fat meal increases absorption

Alcohol · moderate

Increased GI risk

Pharmacokinetics

Half-life: 11 hours
Protein binding: 97%
Metabolised by: CYP2C9
Inhibits: CYP2D6

Pregnancy & lactation

Not recorded for Celecoxib. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.