Carboplatin

Forms DNA crosslinks; less nephrotoxic than cisplatin

Therapeutic range

5–7 mg*min/mL

AUC 5-7 by Calvert formula

No curated interaction pairs are recorded for Carboplatin. This is not a statement that none exist — check a full interaction reference before combining.

• Myelosuppression (dose-limiting)
• Nausea
• Vomiting
• Electrolyte wasting

Half-life

1.1-2 hours (initial); 2.6-5.9 hours (terminal)

Protein binding

24-50%

Clearance

6.5 L/h

adult oncology patients (Calvert formula)

Volume of distribution

16 L

Renally eliminated

65%

Dose review in renal impairment

Model

1-compartment

Not recorded for Carboplatin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.