Serotonin syndrome risk when combined with other serotonergic drugs
Mechanism of action
Partial agonist at 5-HT1A receptors; no GABA activity
Interactions
No curated interaction pairs are recorded for Buspirone. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Dizziness
Nausea
Headache
Nervousness
Lightheadedness
Food, alcohol & herbal
Food
Take consistently with or without food; grapefruit increases levels
Alcohol · moderate
May increase CNS depression
Herbal
St. John's Wort (major) — Risk of serotonin syndrome
Pharmacokinetics
Half-life
2-3 hours
Protein binding
86%
Metabolised by
CYP3A4
Pregnancy & lactation
Not recorded for Buspirone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
