Baclofen

Lioresal, Gablofen

Muscle relaxant • GABA-B agonist

CNS Depressant

Half-life

3-4 hours

Protein Binding

30%

Metabolized By

N/A

External

Activates GABA-B receptors, inhibiting spinal cord reflexes

Drug Class

Muscle relaxant

Subclass

GABA-B agonist

LioresalGablofen

Half-life

3-4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

30%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

•Abrupt discontinuation may cause withdrawal syndrome including hallucinations, seizures