PharmaGraphX

Log in Get Started

Baclofen

Lioresal, Gablofen, Ozobax, Lyvispah, Fleqsuvy

Muscle relaxant • GABA-B agonist

Premium

CNS Depressant

Half-life

3-4 hours

Protein Binding

30%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Abrupt discontinuation may cause withdrawal syndrome including hallucinations, seizures

Clinical alerts

Boxed warning

1 boxed warning

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Activates GABA-B receptors, inhibiting spinal cord reflexes

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Rumination Syndrome
·Benzodiazepine Dependence
·Herpes Zoster
·Pain
·Hand Osteoarthritis

Interactions

No curated interaction pairs are recorded for Baclofen. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Drowsiness
Weakness
Dizziness
Nausea
Hypotension

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Pharmacokinetics

Half-life: 3-4 hours
Protein binding: 30%

Pregnancy & lactation

Not recorded for Baclofen. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Baclofen

Lioresal, Gablofen, Ozobax, Lyvispah, Fleqsuvy

Muscle relaxant • GABA-B agonist

Premium

CNS Depressant

Half-life

3-4 hours

Protein Binding

30%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Abrupt discontinuation may cause withdrawal syndrome including hallucinations, seizures

Clinical alerts

Boxed warning

1 boxed warning

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Activates GABA-B receptors, inhibiting spinal cord reflexes

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Rumination Syndrome
·Benzodiazepine Dependence
·Herpes Zoster
·Pain
·Hand Osteoarthritis

Interactions

No curated interaction pairs are recorded for Baclofen. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Drowsiness
Weakness
Dizziness
Nausea
Hypotension

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Pharmacokinetics

Half-life: 3-4 hours
Protein binding: 30%

Pregnancy & lactation

Not recorded for Baclofen. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement