Aspirin

Bayer, Ecotrin, Pamprin Max Formula, Stanback Headache Powder Reformulated Jan 2011, BC Arthritis, BC Original Formula, Arthriten Inflammatory Pain, Bromo Seltzer Antacid Pain Reliever, Exaprin, Backaid IPF, Ascomp, Excedrin PM Triple Action, Aspi-Cor, Durlaza, Alka-Seltzer, Yosprala, Aspergum, Anacin, Bayer Aspirin, Bufferin, Excedrin, Norgesic, Norwich Aspirin, P-A-C Analgesic, Saleto, St. Joseph Aspirin, Vanquish, Equagesic, Vazalore, Orphengesic, Exaprin Plus, Excedrin Back & Body, Anacin Advanced Headache Formula, Anacin Aspirin Regimen, Miniprin

Antiplatelet • COX inhibitor / NSAID

Premium

BleedingNephrotoxic

Half-life

15-20 minutes (dose-dependent)

Protein Binding

80-90%

Metabolized By

CYP2C9

External

Drugs.com

Clinical alerts

Bleeding risk

Additive with other antithrombotics and NSAIDs

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Irreversibly inhibits COX-1, preventing thromboxane A2 synthesis

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·HER2-negative Breast Cancer
·Metastatic Breast Cancer
·Metaplastic Breast Carcinoma
·TNBC - Triple-Negative Breast Cancer
·Acute Ischemic Stroke

Interactions

2 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
warfarin	major	Significantly increased risk of major bleeding, including GI and intracranial hemorrhage.
cocaine	moderate	Increased bleeding risk from cocaine-induced vascular trauma with impaired hemostasis

Common adverse effects

GI upset
Bleeding
Tinnitus

Food, alcohol & herbal

Food

Take with food to reduce GI irritation

Alcohol · major

Significantly increases GI bleeding risk. Avoid concurrent use.

Herbal

Ginkgo biloba (moderate) — Additive bleeding risk
Willow bark (moderate) — Contains salicylates; additive effect

Pharmacokinetics

Half-life: 15-20 minutes (dose-dependent)
Protein binding: 80-90%
Metabolised by: CYP2C9

Pregnancy & lactation

Not recorded for Aspirin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement