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  3. /Anastrozole

Anastrozole

Arimidex

Antineoplastic • Aromatase inhibitor

Premium

Half-life

50 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Potent, selective non-steroidal aromatase inhibitor

Indications(5)

Breast AdenocarcinomaHormone Receptor PositiveStage IA Breast Cancer AJCC v7Stage IB Breast Cancer AJCC v7Stage IIA Breast Cancer AJCC v6 and v7

Classification

Drug Class

Antineoplastic

Subclass

Aromatase inhibitor

Brand Names

Arimidex

Key Properties

Half-life

50 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Anastrozole Drug Profile | PharmaGraphX