Amphotericin B Drug Profile

Boxed warning

Reserved for progressive, potentially life-threatening fungal infections

Clinical alerts

Boxed warning

1 boxed warning

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Hepatotoxic

Monitor liver function

Mechanism of action

Binds to ergosterol in fungal cell membrane, causing membrane disruption and cell death

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Invasive Fungal Infections
·Neutropenic Fever
·Visceral Leishmaniasis
·IBD
·Crohn Disease

Interactions

No curated interaction pairs are recorded for Amphotericin B. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Infusion reactions (fever, chills, rigors)
Nephrotoxicity
Hypokalemia
Hypomagnesemia
Anemia

Food, alcohol & herbal

Alcohol · moderate

May worsen hepatotoxicity

Pharmacokinetics

Half-life: 15 days
Protein binding: >90%

Pregnancy & lactation

Not recorded for Amphotericin B. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.