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Fungizone, AmBisome, Abelcet
Antifungal • Polyene antifungal
Binds to ergosterol in fungal cell membrane, causing membrane disruption and cell death
Drug Class
Antifungal
Subclass
Polyene antifungal
Half-life
15 days
Time for plasma concentration to decrease by 50%
Protein Binding
>90%
Fraction bound to plasma proteins
Therapeutic Index
Narrow
Margin between therapeutic and toxic doses