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  3. /Amphotericin B

Amphotericin B

Fungizone, AmBisome, Abelcet

Antifungal • Polyene antifungal

Premium
NTIQT RiskHepatotoxicNephrotoxic

Half-life

15 days

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Binds to ergosterol in fungal cell membrane, causing membrane disruption and cell death

Indications(5)

Invasive Fungal InfectionsNeutropenic FeverVisceral LeishmaniasisIBDCrohn Disease

Classification

Drug Class

Antifungal

Subclass

Polyene antifungal

Brand Names

FungizoneAmBisomeAbelcet

Key Properties

Half-life

15 days

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Amphotericin B Drug Profile | PharmaGraphX