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  3. /Amlodipine

Amlodipine

Norvasc, Tribenzor, Exforge HCT, Twynsta, Prestalia, Consensi, Lotrel, Katerzia, Norliqva, Sdamlo, Widaplik, Caduet, Exforge, Azor

Calcium channel blocker • Dihydropyridine CCB

Premium

Half-life

30-50 hours

Protein Binding

Metabolized By

CYP3A4, CYP3A5

External

Drugs.com

Mechanism of Action

Blocks L-type calcium channels in vascular smooth muscle, causing vasodilation

Indications(5)

HER2-negative Breast CancerMetastatic Breast CancerMetaplastic Breast CarcinomaTNBC - Triple-Negative Breast CancerHypertension

Classification

Drug Class

Calcium channel blocker

Subclass

Dihydropyridine CCB

Brand Names

NorvascTribenzorExforge HCTTwynstaPrestaliaConsensiLotrelKaterziaNorliqvaSdamloWidaplikCaduetExforgeAzor

Key Properties

Half-life

30-50 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Amlodipine Drug Profile | PharmaGraphX