Amitriptyline

Elavil

Uncategorized

Standard

Half-life

10-50 hours

Protein Binding

96%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Suicidality in children/adolescents/young adults

Clinical alerts

Boxed warning

1 boxed warning

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Anticholinergic

Adds to anticholinergic burden, particularly in older patients

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Inhibits reuptake of serotonin and norepinephrine; blocks muscarinic, H1, and alpha-1 receptors

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Painful Diabetic Neuropathy (PDN)
·Peripheral Neuropathy With Type 2 Diabetes
·Vegan Diet
·Interstitial Cystitis
·Levator Spasm

Interactions

No curated interaction pairs are recorded for Amitriptyline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Dry mouth
Constipation
Drowsiness
Weight gain

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 10-50 hours
Protein binding: 96%
Metabolised by: CYP2D6, CYP2C19, CYP3A4

Pregnancy & lactation

Not recorded for Amitriptyline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Amitriptyline

Elavil

Uncategorized

Standard

Half-life

10-50 hours

Protein Binding

96%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Suicidality in children/adolescents/young adults

Clinical alerts

Boxed warning

1 boxed warning

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Anticholinergic

Adds to anticholinergic burden, particularly in older patients

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Inhibits reuptake of serotonin and norepinephrine; blocks muscarinic, H1, and alpha-1 receptors

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Painful Diabetic Neuropathy (PDN)
·Peripheral Neuropathy With Type 2 Diabetes
·Vegan Diet
·Interstitial Cystitis
·Levator Spasm

Interactions

No curated interaction pairs are recorded for Amitriptyline. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Dry mouth
Constipation
Drowsiness
Weight gain

Food, alcohol & herbal

Alcohol · major

Severe CNS depression

Herbal

St. John's Wort (major) — Serotonin syndrome risk

Pharmacokinetics

Half-life: 10-50 hours
Protein binding: 96%
Metabolised by: CYP2D6, CYP2C19, CYP3A4

Pregnancy & lactation

Not recorded for Amitriptyline. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Amitriptyline Drug Profile | PharmaGraphX