PharmaGraphX

Log in Get Started

Allopurinol

Zyloprim, Aloprim

Antigout • Xanthine oxidase inhibitor

Premium

Nephrotoxic

Half-life

1-2 hours (active metabolite 18-30 hours)

Protein Binding

Negligible

Metabolized By

N/A

External

Drugs.com

Boxed warning

Severe hypersensitivity reactions including SJS/TEN and DRESS (HLA-B*5801 associated)

Clinical alerts

Boxed warning

1 boxed warning

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Inhibits xanthine oxidase, reducing uric acid production

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Salt; Excess
·Blood Pressure Disorders
·Gout
·Tophaceous Gout
·Adenylosuccinate Lyase Deficiency

Interactions

No curated interaction pairs are recorded for Allopurinol. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Rash
Acute gout flare (initially)
Nausea
Diarrhea

Food, alcohol & herbal

Food

Take after meals to reduce GI upset

Alcohol · moderate

Alcohol may reduce allopurinol effectiveness

Pharmacokinetics

Half-life: 1-2 hours (active metabolite 18-30 hours)
Protein binding: Negligible

Pregnancy & lactation

Not recorded for Allopurinol. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Allopurinol

Zyloprim, Aloprim

Antigout • Xanthine oxidase inhibitor

Premium

Nephrotoxic

Half-life

1-2 hours (active metabolite 18-30 hours)

Protein Binding

Negligible

Metabolized By

N/A

External

Drugs.com

Boxed warning

Severe hypersensitivity reactions including SJS/TEN and DRESS (HLA-B*5801 associated)

Clinical alerts

Boxed warning

1 boxed warning

Nephrotoxic

Monitor renal function; avoid other nephrotoxins where possible

Mechanism of action

Inhibits xanthine oxidase, reducing uric acid production

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Salt; Excess
·Blood Pressure Disorders
·Gout
·Tophaceous Gout
·Adenylosuccinate Lyase Deficiency

Interactions

No curated interaction pairs are recorded for Allopurinol. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Rash
Acute gout flare (initially)
Nausea
Diarrhea

Food, alcohol & herbal

Food

Take after meals to reduce GI upset

Alcohol · moderate

Alcohol may reduce allopurinol effectiveness

Pharmacokinetics

Half-life: 1-2 hours (active metabolite 18-30 hours)
Protein binding: Negligible

Pregnancy & lactation

Not recorded for Allopurinol. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement