Allopurinol

Zyloprim, Aloprim

Antigout • Xanthine oxidase inhibitor

Nephrotoxic

Half-life

1-2 hours (active metabolite 18-30 hours)

Protein Binding

Negligible

Metabolized By

N/A

External

Inhibits xanthine oxidase, reducing uric acid production

Drug Class

Antigout

Subclass

Xanthine oxidase inhibitor

ZyloprimAloprim

Half-life

1-2 hours (active metabolite 18-30 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

Negligible

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

•Severe hypersensitivity reactions including SJS/TEN and DRESS (HLA-B*5801 associated)